Biocompatibility of designed MicNo-ZnO particles: Cytotoxicity, genotoxicity and phototoxicity in human skin keratinocyte cells.

Recently, designed platelet shaped micron particles that are composed of nano primary particles, called MicNo (=Micron+naNo) particles, have been developed to exploit the benefits of nano size, while removing the adverse effects of nanoparticles. It has been shown that MicNo-ZnO particles exhibit both micron and nanosized particle characteristics.

The research objective of this study was to evaluate in vitro cytotoxicity, genotoxicity and phototoxicity behaviors of designed MicNo-ZnO particles over human epidermal keratinocyte (HaCaT) cells. MicNo-ZnO particles exhibit much less cytotoxicity with IC50 concentrations between 40 and 50μg/ml, genotoxicity above 40μg/ml and lower photo genotoxicity under UVA on HaCaT than the ZnO nanoparticles.

Safe, Transparent and Reliable mineral-based UV-filter for sunscreens and other cosmetics: MicNo® -ZnO

The ozone layer, the natural UV-filter of the earth, is getting thinner. As a result, more harmful rays from the sun are passing through this natural barrier. UVA and UVB rays passing through the barrier can cause DNA damage in the skin which can lead to photo aging and more critically skin cancer. There are two physical filters used in sunscreen products approved by Food and Drug Administration (FDA) and European Union (EU); Zinc Oxide (ZnO) and Titanium dioxide (TiO2). Between these two systems, ZnO is the only sunscreen ingredient that extensively covers both UVA and UVB as reported by FDA.