Recently, designed platelet shaped micron particles called MicNo (=Micron+naNo) particles, have been developed to exploit the benefits of nano size, while removing the adverse effects of nanoparticles. It has been shown that MicNo ZnO particles exhibit both micron and nanosized particle characteristics.

Although physical and chemical properties of MicNo ZnO particles have been studied, their biocompatibility has not yet been evaluated. Accordingly, the research objective of this study was to evaluate in vitro cytotoxicity, genotoxicity and phototoxicity behaviors of designed MicNo ZnO particles over human epidermal keratinocyte (HaCaT) cells.

zno particles

MicNo ZnO particles exhibit much less cytotoxicity with IC50 concentrations between 40 and 50μg/ml, genotoxicity above 40μg/ml and lower photo genotoxicity under UVA on HaCaT than the ZnO nanoparticles. Although their chemistries are the same, the source of this difference in toxicity values may be attributed to size differences between the particles that are probably due to their ability to penetrate into the cells. In the present study, the expansive and detailed in vitro toxicity tests show that the biocompatibility of MicNo ZnO particles is much better than that of the ZnO nanoparticles. Consequently, MicNo ZnO particles can be considered an important active ingredient alternative for sunscreen applications due to their safer characteristics with respect to ZnO nanoparticles.

Entekno Materials have designed and developed the innovative MicNo® ZnO Particle Technology to allow sunscreen formulators to combine the benefits and overcome the disadvantages associated with micron & nano ZnO as a UV filter. MicNo® particles are scientifically engineered novel platelet shaped micron particles.

The uniquely designed morphology of MicNo® particles enables them to behave like safe micron particles over the skin & like transparent under the light.